Cat-Tails for Two ® 1953 !(W.A.T.C.H) oNlInE!. ©1440p! fUlL MOVIE

Title	Cat-Tails for Two (1953)
Time	02h 04 min
Released	67 years 3 months 11 days ago
File Name	cat-tails-for-two_MrGRy.mkv
Quality	MPEG-1 1080p WEBrip
Size	794 MB

Overview

Two cats try to catch Speedy Gonzales aboard a ship, without much success.

Cat-Tails for Two (1953)

Genre: Animation
Cast: Mel Blanc, Stan Freberg
Crew: Robert McKimson, Edward Selzer, Carl W. Stalling
Release: 1953-08-29
Budget: $7,303,817
Revenue: $21,593,503
Computer Scientist: Juanita Leffler
Human Resource Director: Myrl Lang
Metal Molding Operator: Joan Schuster
Rehabilitation Counselor: Myron Heller
Camera Operator: Roman Ankunding DVM
Fishing OR Forestry Supervisor: Ms. Christa Marquardt
Web Developer: Everardo Ledner
Roof Bolters Mining: Prof. Mathilde Breitenberg
Sales Representative: Dr. Keith Crist
Teacher: Prof. Tyrell Gibson I

The Ribosome-associated Quality Control (RQC) pathway co-translationally marks incomplete polypeptides from stalled translation with two signals that trigger their proteasome-mediated degradation. The E3 ligase Ltn1 adds ubiquitin and Rqc2 directs the large ribosomal subunit to append carboxy-terminal alanine and threonine residues (CAT tails). When excessive amounts of incomplete polypeptides evade Ltn1, CAT-tailed proteins accumulate and can self-associate into aggregates. CAT tail aggregation has been hypothesized to either protect cells by sequestering potentially toxic incomplete polypeptides or harm cells by disrupting protein homeostasis. To distinguish between these possibilities, we modulated CAT tail aggregation in Saccharomyces cerevisiae with genetic and chemical tools to analyze CAT tails in aggregated and un-aggregated states. We found that enhancing CAT tail aggregation induces proteotoxic stress and antagonizes degradation of CAT-tailed proteins, while inhibiting aggregation reverses these eff.
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Aggregation of CAT tails blocks their degradation and causes proteotoxicity in S. cerevisiae.
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Cat-Tails for Two - Speedy Gonzales: Two cats, one crafty but ill-fated, the other a lunkheaded oaf, decide to hunt mice on a Mexican ship and meet Speedy Gonzales, the fastest mouse in all Mexico. Not surprisingly, all their schemes for catching Speedy fail, with violent consequences for the smarter cat.

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